Clinical Trial Simulations: Applications and Trends (AAPS Advances in the Pharmaceutical Sciences Series)

Clinical Trial Simulations: Applications and Trends (AAPS Advances in the Pharmaceutical Sciences Series) Review

This edition includes both updates and new uses and issues concerning CTS, along with case studies of how clinical trial simulations are being applied in various therapeutic and application areas. Importantly, the book expands on the utility of CTS for informing decisions during drug development and regulatory review. Each chapter author was selected on the basis of demonstrated expertise in state-of-the-art application of CTS. The target audience for this volume includes researchers and scientists who wish to consider use of simulations in the design, analysis, or regulatory review and guidance of clinical trials. This book does not embrace all aspects of trial design, nor is it intended as a complete recipe for using computers to design trials. Rather, it is an information source that enables the reader to gain understanding of essential background and knowledge for practical applications of simulation for clinical trial design and analysis. It is assumed that the reader has a working understanding of pharmacokinetics and pharmacodynamics, modeling, pharmacometric analyses, and/or the drug development and regulatory processes.

Introduction to Computational Science: Modeling and Simulation for the Sciences

Introduction to Computational Science: Modeling and Simulation for the Sciences Review

Computational science is a quickly emerging field at the intersection of the sciences, computer science, and mathematics because much scientific investigation now involves computing as well as theory and experiment. However, limited educational materials exist in this field. Introduction to Computational Science fills this void with a flexible, readable textbook that assumes only a background in high school algebra and enables instructors to follow tailored pathways through the material. It is the first textbook designed specifically for an introductory course in the computational science and engineering curriculum.

The text embraces two major approaches to computational science problems: System dynamics models with their global views of major systems that change with time; and cellular automaton simulations with their local views of how individuals affect individuals. While the text is generic, an extensive author-generated Web-site contains tutorials and files in a variety of software packages to accompany the text.

• Generic software approach in the text
• Web site with tutorials and files in a variety of software packages
• Engaging examples, exercises, and projects that explore science
• Additional, substantial projects for students to develop individually or in teams
• Consistent application of the modeling process
• Quick review questions and answers
• Projects for students to develop individually or in teams
• Reference sections for most modules, as well as a glossary
• Online instructor's manual with a test bank and solutions